RAF Typhoon jets have operated alongside France's air force in a coordinated attack targeting an underground arms cache in Syrian territory used by the IS group, per a report from the British defence ministry.
The location, identified by surveillance, was assessed as containing munitions and bombs, the release indicated, and was positioned in mountainous terrain just above Palmyra in central Syria.
"The RAF jets used laser-guided Paveway IV weapons to strike a several approach shafts leading to the site... preliminary assessments are that the target was engaged successfully," the MoD said.
There was no evidence of any civilian casualties in the strike late on Saturday and every plane involved made a safe return, the defence officials confirmed.
The British jets were supported by a Voyager tanker plane.
IS - alternatively referred to as the so-called Islamic State - established extremist governance over significant areas in Syria and Iraq until 2019.
"This strike demonstrates our UK leadership, and commitment to stand shoulder to shoulder with our partners, to eliminate any re-emergence of the terrorist group and their dangerous and violent ideologies in the region," Britain's Defence Chief John Healey stated.
British military aircraft have carried out surveillance missions over Syrian airspace to "forestall any attempted comeback" of Islamic State subsequent to its routing at the battle of Baghuz in 2019, the ministry said.
"I extend gratitude to the personnel of British forces involved in this strike for their professionalism and their courage," he commented. "Including them were thousands of British personnel on duty over the festive period. This mission, to remove terrorist threats who pose a risk to our safety, shows how our armed forces are ready to step up, throughout the year, ensuring Britain's security within its borders and strong abroad."
Last December, the United States armed forces carried out what it described as a "massive strike" against Islamic State objectives in the country, after an attack killed two US troops and a local interpreter in Palmyra.
The U.N. says IS still maintains between 5,000 and 7,000 fighters in Iraq and Syria.